San Francisco · Staff Software Engineer · Clinical AI
ABOUT DOUBLE BLIND BIO
Double Blind Bio is building the infrastructure layer for clinical trials. Their AI agents automate the workflows that slow research sites down: finding trials, activating them, and running them from start to finish. For drug sponsors, Double Blind Bio provides real-time visibility into site activity and measurably shorter trial startup times.
The numbers speak to the scale of the problem they are solving: more than 400 clinical research sites are already using the platform. Founded in 2025 and backed by SignalFire and Define Ventures, Double Blind Bio is a small, high-ownership team at an early and critical stage of building something genuinely consequential in healthcare.
THE CHALLENGE
At seed stage with a team of under 10 people, every engineering hire carries significant weight. Double Blind Bio needed a Staff Software Engineer who could own AI-powered products end to end, including agentic workflows and LLM features with production evaluations, while also serving as a technical lead and mentor for three junior engineers.
The role demanded a rare combination: someone with the seniority and judgment to shape technical direction alongside the CTO, the hands-on coding capability to build and ship daily, and the breadth to span frontend, backend, infrastructure, and data pipelines. Experience with LLMs in production and familiarity with tools like LangSmith, Braintrust, or Weights & Biases was essential.
WHY AMIGOS?
Double Blind Bio engaged us because of our growing track record placing senior engineers at seed-stage AI companies in San Francisco. At this stage, the wrong hire is costly in ways that go beyond time and money. They needed a partner who understood what Staff-level really means in a founding-team context and who could access candidates who wouldn’t be visible through conventional channels.
OUR APPROACH
We started with an in-depth briefing to understand not just the technical requirements but what kind of engineer thrives at this stage: high ownership, low ego, genuinely excited by the mission. We then ran a targeted search focused on engineers with hands-on LLM and agentic AI experience in production environments, cross-referencing technical depth with the founding-team mindset the role required.
THE RESULT
We successfully placed a Staff Software Engineer at Double Blind Bio, bringing the AI product ownership and technical leadership the team needed to accelerate their platform development. The placement supports Double Blind Bio as they continue to scale their clinical trial automation product across research sites in the US.